Synthesis and Evalution of Amide Prodrugs of Diclofenac

“Prodrugs Approach” is a versatile approach in solving the problems associated with drug molecules. Diclofenac is a pain reliever in variety of painful conditions but it has some side effects i.e. absorption, toxicity, distribution, instability, formulation etc. These side effects can be reduced by “Prodrugs Approach”. In the present research work some amide Prodrugs of Diclofenac have been synthesized via acid amine coupling of Diclofenac and ester derivatives of amino acids using HOBT, NMM and EDC.HCl in dichloromethane medium. These newly synthesized Prodrugs were analyzed by NMR and IR spectroscopy. These newly synthesized Prodrugs were analyzed by NMR and IR spectroscopy. All the compounds were evaluated for analgesic activity by acetic acid induced writhing and anti-inflammatory activity by Carragennan Induced Rat hind Paw method.